| 2011年
12月31日 | 2012年
12月31日 | 2013年
12月31日 | 2014年
12月31日 | 2015年
12月31日 | 2016年
12月31日 | 2017年
12月31日 | 2018年
12月31日 | 2019年
12月31日 | 2020年
12月31日 | 2021年
12月31日 | 2022年
12月31日 |
|---|
| Net loss | - | - | - | - | - | - | - | 681 | -441 | -444 | -524 | -368 |
|---|
| Non-cash royalty revenue related to the sales of future royalties | - | 11 | 33 | 55 | 77 | 107 | 138 | 171 | 207 | 256 | 333 | 403 |
|---|
| Non Cash Interest Expense Related To Sale Of Royalties | - | - | - | 61 | 82 | 102 | 120 | 142 | 167 | 197 | 244 | 273 |
|---|
| Loss on revaluation of liability related to the sale of future royalties | - | - | - | - | - | - | - | - | - | - | -24 | - |
|---|
| Change in fair value of development derivative liability | - | - | - | - | - | - | - | - | - | - | -8 | 33 |
|---|
| Research and Development in Process | - | - | - | - | - | - | - | - | - | - | 17 | 5 |
|---|
| Stock-based compensation | - | - | - | 17 | 20 | 26 | 37 | 88 | 100 | 94 | 95 | 57 |
|---|
| Depreciation and amortization | 15 | 15 | 14 | 13 | 13 | 15 | 15 | 11 | 13 | 14 | 14 | 13 |
|---|
| Deferred income tax expense | - | - | - | - | - | - | - | - | -0 | -0 | -0 | 3 |
|---|
| Asset Impairment Charges | - | - | - | - | - | - | - | - | - | - | - | 66 |
|---|
| (Gain) loss on sale or disposal of property, plant and equipment, net | - | - | - | - | - | - | - | - | - | - | - | 3 |
|---|
| Impairment Of Equipment From Terminated Program | - | - | - | - | - | - | 15 | - | - | 20 | - | - |
|---|
| Amortization of premiums (discounts), net and other non-cash transactions | - | - | - | - | - | - | - | - | - | - | -7 | 2 |
|---|
| Accounts receivable | -20 | 1 | -4 | 1 | 16 | -4 | -11 | 26 | -6 | -2 | -12 | -17 |
|---|
| Inventory | 5 | 6 | -5 | -0 | -2 | -0 | -0 | 1 | 1 | 3 | 1 | 3 |
|---|
| Operating leases, net | - | - | - | - | - | - | - | - | -13 | -3 | -2 | 3 |
|---|
| Other assets | 12 | -6 | -6 | 3 | 1 | 0 | 5 | 32 | -1 | -4 | 3 | -7 |
|---|
| Accounts payable | -3 | -0 | 6 | -6 | -0 | 1 | 2 | 1 | 13 | 2 | -12 | 3 |
|---|
| Accrued compensation | 4 | -4 | 5 | -9 | 0 | 12 | -10 | 2 | 2 | 5 | 1 | -6 |
|---|
| Other accrued expenses | - | - | - | - | -2 | 0 | 6 | 28 | 4 | 9 | -24 | -13 |
|---|
| Deferred revenue | - | - | - | - | - | - | - | -15 | -17 | -6 | -1 | -1 |
|---|
| Net cash used in operating activities | -114 | -130 | -39 | - | - | - | - | 718 | -329 | -313 | -413 | -304 |
|---|
| Purchases of investments | - | - | - | - | - | - | - | 2,271 | 1,381 | 988 | 961 | 468 |
|---|
| Maturities of investments | 383 | 308 | 319 | 248 | 227 | 254 | 348 | 891 | 1,614 | 1,449 | 1,167 | 826 |
|---|
| Sales of investments | - | - | - | - | - | - | - | 12 | - | 42 | 12 | - |
|---|
| Purchases of property, plant and equipment | 10 | 11 | 4 | 10 | 11 | 6 | 10 | 14 | 26 | 7 | 15 | 6 |
|---|
| Sales of property, plant and equipment | - | - | - | - | - | - | - | 3 | - | - | - | 13 |
|---|
| Net cash provided by investing activities | -112 | 113 | 50 | - | - | - | - | -1,380 | 207 | 496 | 203 | 366 |
|---|
| Proceeds From Sale of Future Royalties, Net | - | - | - | - | - | - | - | - | - | 146 | - | - |
|---|
| Repayment of senior notes | - | - | - | - | 125 | - | - | - | - | 250 | - | - |
|---|
| Cash receipts from development derivative liability | - | - | - | - | - | - | - | - | - | - | 3 | 1 |
|---|
| Proceeds from shares issued under equity compensation plans | - | 4 | 8 | 47 | 32 | 20 | 60 | 62 | 23 | 23 | 33 | 1 |
|---|
| Net cash provided by (used in) financing activities | 222 | 27 | 2 | - | - | - | - | 852 | 23 | -80 | 36 | 2 |
|---|
| Effect of foreign exchange rates on cash and cash equivalents | - | - | - | - | - | - | - | - | -0 | 0 | -0 | -0 |
|---|
| Net increase (decrease) in cash and cash equivalents | - | - | - | - | - | - | - | 190 | -99 | 103 | -174 | 63 |
|---|
| Cash paid for interest | - | - | - | - | - | - | - | 19 | 19 | 10 | - | - |
|---|
| Income Taxes Paid, Net | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
|---|
| Right-of-Use Asset Obtained in Exchange for Operating Lease Liability | - | - | - | - | - | - | - | - | 58 | 2 | 1 | - |
|---|