大株主
| （単位：千株） | 2015/12 | 2016/12 | 2017/12 | 2018/12 | 2019/12 | 2020/12 | 2021/12 | 2022/12 | 2023/12 | 2024/12 |
|---|---|---|---|---|---|---|---|---|---|---|
| ROCHE HOLDING LTD | 335,223 59.89% | 335,223 59.89% | 335,223 61.25% | 335,223 61.22% | 1,005,670 61.17% | 1,005,670 61.16% | 1,005,670 61.13% | 1,005,670 61.12% | 1,005,670 61.11% | |
| 日本マスタートラスト信託銀行 | 19,857 3.54% | 22,271 3.97% | 25,154 4.49% | 29,342 5.36% | 30,258 5.52% | 105,907 6.44% | 144,080 8.76% | 148,700 9.03% | 145,198 8.82% | 143,365 8.71% |
| 日本カストディ銀行 | 9,849 0.59% | 10,253 0.62% | 61,476 3.73% | 59,737 3.63% | 56,749 3.44% | |||||
| STATE STREET BANK ANDTRUST COMPANY | 12,283 0.74% | 12,815 0.77% | 14,111 0.85% | 25,232 1.53% | 29,340 1.78% | |||||
| STATE STREET BANK WESTCLIENT-TREATY | 14,460 0.87% | 13,782 0.83% | 14,445 0.87% | 14,334 0.87% | 15,034 0.91% | |||||
| JP MORGAN CHASE BANK | 4,476 0.79% | 3,792 0.67% | 13,924 2.54% | 8,755 0.53% | 9,375 0.56% | 9,240 0.56% | ||||
| JPモルガン証券 | 15,441 0.93% | 9,987 0.6% | ||||||||
| NORTHERN TRUST CO.SUB A/C AMERICAN CLIENTS | 3,528 0.64% | 8,871 0.53% | 11,266 0.68% | 9,334 0.56% | ||||||
| 住友生命保険相互会社 | 3,000 0.53% | 9,000 0.54% | 9,000 0.54% | 9,000 0.54% | 9,000 0.54% | |||||
| NORTHERN TRUST CO.RE NON TREATY CLIENTS ACCOUNT | 19,120 1.16% | |||||||||
| SMBC日興証券 | 18,063 1.09% | 19,524 1.18% | 11,032 0.67% | |||||||
| SSBTC CLIENT OMNIBUSACCOUNT | 14,518 0.88% | 10,484 0.63% | ||||||||
| JP MORGAN CHASE BANK385632 | 60,658 3.68% | 13,706 0.83% | ||||||||
| JP MORGAN CHASE BANK380055 | 16,388 2.99% | |||||||||
| 日本トラスティ・サービス信託銀行 | 17,244 3.08% | 18,540 3.31% | 3,794 0.67% | 3,748 0.68% | 4,230 0.77% | |||||
| STATE STREET BANK AND TRUST COMPANY | 15,614 2.85% | 10,537 1.92% | ||||||||
| STATE STREET BANK WEST CLIENT-TREATY | 4,262 0.76% | 4,231 0.77% | 3,998 0.73% | |||||||
| SSBTC CLIENT OMNIBUS ACCOUNT | 3,651 0.66% | 3,795 0.69% | ||||||||
| 資産管理サービス信託銀行 | 3,594 0.64% | 4,045 0.72% | 3,829 0.69% | |||||||
| MSCO CUSTOMER SECURITIES | 3,219 0.57% | |||||||||
| STATE STREET BANK WEST CLIENT - TREATY | 3,761 0.67% | |||||||||
| 中外製薬社員持株会 | 3,158 0.56% | |||||||||
| ロシュ・ホールディング・リミテッド | 335,223 59.89% | |||||||||
| ジェー ピー モルガン チェース バンク | 6,374 1.13% | |||||||||
| ゴールドマン・サックス・アンド・カンパニーレギュラーアカウント | 3,660 0.65% | |||||||||
| ステート ストリート バンク ウェスト クライアント トリーティー | 3,644 0.65% | |||||||||
| 東京海上日動火災保険 | 3,282 0.58% | |||||||||
| ザ バンク オブ ニューヨーク メロン SA／NV 10 | 3,232 0.57% | |||||||||
| 計 | 404,611 72.29% | 413,686 73.91% | 421,046 75.22% | 429,978 78.57% | 428,793 78.31% | 1,300,373 79.1% | 1,285,469 78.17% | 1,308,393 79.53% | 1,309,186 79.57% | 1,302,176 79.13% |