| 2018年
12月31日 | 2019年
12月31日 | 2020年
12月31日 | 2021年
12月31日 | 2022年
12月31日 |
|---|
| Net loss | -38,980,313 | -36,698,957 | -44,784,921 | -44,161,175 | -53,010,382 |
|---|
| Depreciation and amortization | - | 810,782 | 1 | 1 | 922,216 |
|---|
| Stock-based compensation | 7 | 7 | 10 | 12 | 9 |
|---|
| Amortization of operating lease right-of-use asset | - | - | - | 3 | 883,839 |
|---|
| Amortization of Debt Discount (Premium) | - | - | 83,694 | -4,581 | -320,612 |
|---|
| Gain on right-of-use asset modification | - | - | - | - | 276,633 |
|---|
| Loss on disposal of fixed asset | -3,315 | -54,274 | - | 21,550 | -3,962 |
|---|
| Amortization of Debt Issuance Costs | - | - | - | - | 30,810 |
|---|
| Accretion of final payment of term loan | - | - | - | - | 108,696 |
|---|
| Account receivable | - | 754,898 | 662,584 | 2 | -3,085,275 |
|---|
| Prepaid expenses and other current assets | 701,939 | -487,182 | 381,132 | 50,434 | -33,602 |
|---|
| Other assets | - | -123,437 | 4,971 | -250,000 | - |
|---|
| Deposits | - | -1,559,704 | - | -148,515 | -394,721 |
|---|
| Accounts payable | 376,147 | -1,152,688 | 741,265 | 520,398 | 83,110 |
|---|
| Accrued expenses | 636,975 | 439,290 | 559,859 | 2 | -1,070,580 |
|---|
| Research and development contract liability, current portion | 5 | 928,588 | 503,263 | -7,973,255 | -645,344 |
|---|
| Operating lease liability | - | -4,277,544 | 5 | 3 | -735,068 |
|---|
| Net cash used in operating activities | -26,410,968 | -30,796,910 | -32,494,034 | -38,837,166 | -41,805,954 |
|---|
| Purchases of property and equipment | 2 | 46,353 | 595,259 | 913,039 | 170,746 |
|---|
| Cash received from sale of fixed asset | - | 127,500 | - | 21,550 | 6,205 |
|---|
| Redemption of marketable securities | -21,000,000 | -18,500,000 | -15,000,000 | -10,000,000 | -5,000,000 |
|---|
| Purchases of marketable securities | 40 | 15 | - | - | 29 |
|---|
| Net cash provided by investing activities | -20,354,246 | 3 | 4 | 9 | -24,609,877 |
|---|
| Proceeds From At Time Market Offering Net Of Commission And Fees | - | - | - | - | 17 |
|---|
| Proceeds from Issuance of Common Stock | - | - | 57 | 17 | 23 |
|---|
| Proceeds from Debt, Net of Issuance Costs | - | - | - | - | 5 |
|---|
| Proceeds from Issuance of Debt | - | - | - | - | 10 |
|---|
| Proceeds from Stock Options Exercised | 12,500 | 2 | 2 | 3 | - |
|---|
| Payment of debt issuance costs | - | - | - | - | 141,749 |
|---|
| Restricted stock awards withheld at vesting to cover taxes | - | 91,027 | 271,051 | 750,183 | 199,873 |
|---|
| Net cash provided by financing activities | 4 | 51 | 59 | 19 | 54 |
|---|
| Net decrease in cash, cash equivalents, and restricted cash | -42,583,365 | 23 | 31 | -10,495,333 | -12,756,698 |
|---|
| Purchases of property and equipment in accounts payable or accrued expenses | - | - | 446,372 | - | -57,312 |
|---|
| Cash paid for interest | - | - | - | - | 570,347 |
|---|
| Right-of-use asset and lease liability (new lease) | - | - | - | - | 11 |
|---|
| Operating lease modification | - | - | 6 | 8 | 8 |
|---|