| 2011年
12月31日 | 2012年
12月31日 | 2013年
12月31日 | 2014年
12月31日 | 2015年
12月31日 | 2016年
12月31日 | 2017年
12月31日 | 2018年
12月31日 | 2019年
12月31日 | 2020年
12月31日 | 2021年
12月31日 | 2022年
12月31日 | 2023年
12月31日 |
|---|
| Net loss | -9,858,895 | -16,416,907 | -12,322,012 | -18,728,734 | -58,981,030 | -60 | -53 | -33 | -32 | -30 | -45 | -57 | -47 |
|---|
| Depreciation and amortization | 107,396 | 126,537 | 141,522 | 155,083 | 160,812 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
|---|
| Non-cash lease expense | - | - | - | - | - | - | - | - | 1 | 0 | 1 | 1 | 1 |
|---|
| Stock-based compensation expense | 2 | 4 | 3 | 3 | 4 | 4 | 5 | 4 | 3 | 3 | 5 | 7 | 6 |
|---|
| Non-cash activity related to the sale of future royalties | - | - | - | - | - | - | - | - | 0 | 0 | 0 | 1 | -0 |
|---|
| Amortization of premiums and discounts on investments | -246,122 | 434,763 | -95,197 | -169,652 | -148,467 | -0 | 0 | 0 | 0 | -0 | -1 | -0 | 1 |
|---|
| Gain on forgiveness of PPP loan | - | - | - | - | - | - | - | - | - | - | 1 | - | - |
|---|
| Accounts receivable | -50,304 | 865,997 | 569,124 | 483,807 | 145,036 | 0 | 1 | -0 | 0 | -0 | 0 | -0 | -0 |
|---|
| Prepaid expenses and other assets | -24,111 | -40,959 | 116,639 | 2,409 | 725,581 | 0 | -0 | -0 | 0 | 0 | 2 | 0 | -0 |
|---|
| Other assets | - | - | - | - | - | - | - | - | - | - | - | 2 | - |
|---|
| Accounts payable and accrued and other liabilities | 416,196 | 20,316 | 181,821 | 360,866 | 2 | 2 | -0 | -2 | 0 | 1 | 5 | -4 | 3 |
|---|
| Accounts payable and accrued and other liabilities | 416,196 | 20,316 | 181,821 | 360,866 | 2 | 2 | -0 | -2 | 0 | 1 | 5 | -4 | 3 |
|---|
| Operating lease liability | - | - | - | - | - | - | - | - | - | - | - | -1 | -1 |
|---|
| Operating lease liability | - | - | - | - | - | - | - | - | - | - | - | -1 | -1 |
|---|
| Total adjustments | 5 | 1 | 3 | 2 | 29 | 25 | 5 | 3 | 6 | 4 | 8 | 2 | 9 |
|---|
| Total adjustments | 5 | 1 | 3 | 2 | 29 | 25 | 5 | 3 | 6 | 4 | 8 | 2 | 9 |
|---|
| Accounts receivable | -50,304 | 865,997 | 569,124 | 483,807 | 145,036 | 0 | 1 | -0 | 0 | -0 | 0 | -0 | -0 |
|---|
| Prepaid expenses and other assets | -24,111 | -40,959 | 116,639 | 2,409 | 725,581 | 0 | -0 | -0 | 0 | 0 | 2 | 0 | -0 |
|---|
| Other assets | - | - | - | - | - | - | - | - | - | - | - | 2 | - |
|---|
| Accounts payable and accrued and other liabilities | 416,196 | 20,316 | 181,821 | 360,866 | 2 | 2 | -0 | -2 | 0 | 1 | 5 | -4 | 3 |
|---|
| Accounts payable and accrued and other liabilities | 416,196 | 20,316 | 181,821 | 360,866 | 2 | 2 | -0 | -2 | 0 | 1 | 5 | -4 | 3 |
|---|
| Operating lease liability | - | - | - | - | - | - | - | - | - | - | - | -1 | -1 |
|---|
| Operating lease liability | - | - | - | - | - | - | - | - | - | - | - | -1 | -1 |
|---|
| Total adjustments | 5 | 1 | 3 | 2 | 29 | 25 | 5 | 3 | 6 | 4 | 8 | 2 | 9 |
|---|
| Total adjustments | 5 | 1 | 3 | 2 | 29 | 25 | 5 | 3 | 6 | 4 | 8 | 2 | 9 |
|---|
| Net cash used in operating activities | -4,563,297 | -15,193,305 | -9,539,577 | - | - | -36 | -48 | -30 | -26 | -26 | -38 | -54 | -38 |
|---|
| Purchases of investments | - | - | - | - | - | - | - | - | - | - | - | 62 | 70 |
|---|
| Sales and maturities of investments | 52 | 46 | 52 | 58 | 117 | 88 | 48 | 48 | 7 | 5 | 45 | 95 | 108 |
|---|
| Purchases of property and equipment | 260,405 | 104,975 | 153,009 | 92,209 | 47,985 | 0 | 0 | 0 | 0 | 1 | - | 0 | - |
|---|
| Net cash provided by investing activities | 10 | -23,003,255 | -13,617,537 | - | - | 30 | -4 | 21 | -4 | -49 | -48 | 33 | 38 |
|---|
| Proceeds from Issuance of Common Stock | 2 | 5 | 4 | 282,799 | 65 | - | 42 | - | - | 159 | - | 6 | 14 |
|---|
| Proceeds from issuance of common stock under the Company’s stock-based compensation plans | - | - | - | - | 1 | 3 | 1 | 0 | 0 | 1 | 0 | 0 | - |
|---|
| Payment of liability of future royalties, net of imputed interest | - | - | - | - | - | - | - | - | 2 | 4 | 4 | 5 | 7 |
|---|
| Payment of liability of future royalties, net of imputed interest | - | - | - | - | - | - | - | - | 2 | 4 | 4 | 5 | 7 |
|---|
| Net cash provided by financing activities | 2 | 36 | 20 | - | - | -1 | 64 | -6 | 23 | 189 | -4 | 1 | 8 |
|---|
| Net cash provided by financing activities | 2 | 36 | 20 | - | - | -1 | 64 | -6 | 23 | 189 | -4 | 1 | 8 |
|---|
| Net increase (decrease) in cash and cash equivalents and restricted cash | - | - | - | - | - | - | - | - | -7 | 114 | -90 | -20 | 7 |
|---|
| Cash paid for interest | - | - | - | - | - | - | - | 4 | 5 | 5 | 4 | 4 | 2 |
|---|
| Decrease in right-of-use assets and operating lease liabilities resulting from lease modification | - | - | - | - | - | - | - | - | -1 | - | -2 | -0 | - |
|---|